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Last night I felt another one of those colds coming on. So I took a huge dose of 40% kudzu extract, 500 mg. No capsule, just swallowed the powder with water (it's not that bitter so it goes down really easily). Within a few minutes I felt, literally, a euphoric stimulation come on. It felt sort of like phenethylamine, in that it was definitely a huge release of norepinephrine and dopamine.
Other effects included oxytocin release via 5-HT1A agonism, so that sets the stage for the euphoria generated by kudzu.
I tried to notice its effect on nicotinic acetylcholine receptors, but I couldn't notice anything as I'm not too familiar with the specific action of kudzu on those receptors.
However, this stuff works GREAT. And supposedly it can be used safely at extremely high doses, due to the relative safety of raw kudzu at high doses as well. Just don't go so high that the stimulation starts to get bad...
As far as a comedown, I'm not sure there is one, but I will have to double check that after my cold wears off. I feel baseline right now, which means gross and lacking norepinephrine and dopamine...
Kudzu does this by antagonizing the 5-HT2C receptor. This is basically the "sickness" receptor, when it turns on it inhibits the release of dopamine and norepinephrine, making you feel down, and lethargic. Blocking it makes you energetic and euphoric. Apparently most people have at least a medium amount of 5-HT2C activation, probably because of non-organic diet and the body's reaction to it.
SWIM also tried this plant extract after I mentioned it to him, and he has something very important to say. SWIM has had cannabis tolerance for several weeks now. Smoking it every day causes this. SWIM no longer got significant visuals, euphoria, or philosophically deep mindset from cannabis, just a good feeling numbness to the body and mind. After trying a similar dose of kudzu with cannabis, SWIM can say with confidence that it brought back most of the original high. Kudzu made cannabis much more psychedelic. I'm not sure that kudzu is a 5-HT2A antagonist, it might just be a weak agonist that prevents more powerful agonists from binding. That, or the dopamine release caused by 5-HT2C antagonization supported the increase in visuals. The huge amount of norepinephrine sped up heart rate, which seemed anciently familiar to SWIM.
Anyway I think this would go great with phenethylamine, as long as a ton of vasodilators are included. :D