Synthetic Cannabinoids

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toastus

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Nov 6 08 12:51 AM

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I'd like to start a discussion of the synthetic cannabinoids and the mixes they are used in.

A friend of mine recently bought a product called Down to Earth Climax XXX: Purple Chronic incense. It is supposed to be incredibly potent and he says two puffs is a normal dose. He wants to know what is in this mix, if any synthetic chemicals are in it, and what receptors this chemical is an agonist at. Does anyone have any of this information?

I personally don't use synthetic cannabinoids, but I'd like to know more about them. I could potentially be interested in a pure CB1 agonist, as long as it's safe. It would be better than phenethylamine, because it would release phenethylamine in just the right areas of the brain (the ones with CB1 receptors...).

What cannabinoids are illegal, and which aren't illegal? I've been searching for this information but I can only find information about the older synthetic compounds, like these: http://www.neurosoup.com/synthetic_cannabinoids.htm

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hendrix

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#1 [url]

Nov 6 08 8:35 AM

I don't have much experience in this area but I'm interested in it.

Funny. I searched Google Products for "Down to Earth Climax XXX" and I got a link to a porn movie. grin

The cannabinoid laws are kept vague on purpose. That way they can prosecute you more easily under the analog act if they so wish.

Between the eyes and ears there lie The sounds of colour and the light of a sigh

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toastus

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#3 [url]

Nov 7 08 4:28 PM

My friend wrote up a short report to post here:

I pull out a pack of synthetic weed my friend brought over. It slightly resembles weed, but looks more flaky and soft than the real thing. Smells like grape juice, but more like processed grape juice than any real juice.

After three or four hits I reached the normal level of high I usually get from a couple bowlfulls of real weed. I finished the first bowl and everything was speeding up rapidly. I got some psychedelic effects at this level. There isn't a lot of zoning out at this level, I can feel everything very strongly and sensitively.

The second bowl was finished and it became hard to move. The universe was pulsing extremely fast and my heart was racing to match it. Energy coursed through my body; I had to lay down or I was going to explode.

The third bowl was finished with the help of a friend and I lay down to trip out. This was honestly a fully psychedelic trip. The normal point of focus that visuals develop strongly at in front of my eyes (I like to think it is the fovea, but it's whatever) has expanded to cover half of my field of vision. I can't think in context of myself anymore, because if I do I will burst from the anxiety of my racing heart. If it weren't for this speedy effect this would be really enjoyable.

I lay there for about an hour until it wore off. Surprisingly this doesn't last as long as THC does. It feels like a pure sativa head high, no stoning or zoning out (until you go for mega doses ;). I think I experienced ego death.

I find the anxiety effect to be like the anxiety from other psychedelics. It's caused by the speedy effect it gives mixed with the psychedelic effect, no doubt. But calmly accepting it as part of the trip ensures that it is kept in check (by not resisting it you effectively eliminate it). So it's no different from other psychedelics, it's just that the speed greatly increases the likelyhood of having a bad trip.

There is actually less muscle tension with this than with real weed. Good after effects for two or three days, like normal weed. I feel happy and strong, energetic, and more in tune with nature. No hangover, unlike other synthetics.

It's also not relaxing like real weed is, either. It is EXTREMELY speedy. Uncomfortably so, but definitely manageable with mental training.

After hearing this, SWIM decided to give it a go. He says it feels like pure CB1 activation, with none of the dissociation of CB2 or any myrcene effects. It feels exactly like extremely high doses of phenethylamine, without any of the hordenine or harmaline effects. Very clear, very speedy, very euphoric until high doses are reached. Then anxiety sets in, yet even the overwhelming anxiety can be eliminated by choosing to not eliminate it.

The psychedelic effects feel different from other psychedelics (different from 5-HT2A agonists). They feel like D2. Having had experience before with D2 agonists (memantine) SWIM can say that this feels like PEA agonizing D2. The speedy effect is from norepinephrine, and the euphoria is dopamine. PEA blocks dopamine and norepinephrine reuptake (slightly, not fully) and increases its rate of release in the brain. CB1 activation causes PEA release, so it should cause these effects. This experiment is consistent with my theory :)

This should actually be a lot like Salvinorin A (forget the speedy effects though). It causes anxiety and D2 visuals. It does not cause the same intensity of visuals that Salvinorin A causes, but they are still there and should have the same quality of character as Salvinorin A, given their mode of action (D2 agonists; Most people think Salvinorin A works through the Kappa-Opioid receptor, but the only effect that has is to upregulate D2 receptors; Salvinorin A has more affinity for the D2 receptor than it does for the Kappa-Opioid receptor, therefore this is the cause of its hallucinogenic effects).

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#4 [url]

Jan 15 09 4:30 PM

SWIM messed around with the JWH series before some of them were made illegal... in fact getting pure crystals and adding them onto various lung healing herbs.  The fear could get tremendous if you aren't used to it. certain ones got more out of control than others. 
SWIM discontinued use after noticing lower back pain around the kidney area and feels that these compounds are probably very damaging.  SWIM also noticed rapid tolerance set in and would almost say he craved them for a little, and consequently had to smoke weed to get off of them.   There is something in weed that balances it out better and prevents the addictive tendencies

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#5 [url]

Jan 15 09 5:57 PM


There is something in weed that balances it out better and prevents the addictive tendencies

-urock

that is probably the CB2 effects i have heard they are supposed to be gaba-geric downstream witch could easily account for the reduction in addiction potential via further downstream nmda antagonism.

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toastus

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#6 [url]

Jan 15 09 11:04 PM

User_name, many synthetic cannabinoids also activate CB2.

In cannabis it's probably oxytocin released through 5-HT1A. CBD is supposed to be a 5-HT1A agonist, or something like that. Also pinene is in cannabis, which is a 5-HT1A agonist.

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#7 [url]

Jan 15 09 11:54 PM

they will all be illegal within a year or two, with the least pleasant and most toxic ones as the final hold-outs. John W. Huffman (the designer of the JWH series) has been publicly outspoken about the likely cardiotoxic effects of the synthetic cannabinoids. I'd source the all natural original if I was you ; )

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toastus

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#11 [url]

Jun 7 09 4:36 AM

Lemongrass blocks the heart racing effects and a lot of the paranoia. Lemon oil will block the rest of the paranoia and should make you feel euphoric.

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sativa

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Jun 7 09 5:47 PM

I've had upto 5 00 capsules of Lemon oil, amazing experience! Have combined Lemon oil with cannabis, and 2ce as well as other psychedelics, and piracetam. It interacts very nicely and is great even on its own!

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