"How potent of a CYP2A6 inhibitor is cannabidiol? - hendrix"
Oh, 2A6, I was thinking of 2D6. From my searching around on the subject, I have only come up with one report , which states:
"Δ9-THC, CBD, and CBN noncompetitively inhibited coumarin 7-hydroxylase activity of recombinant CYP2A6 with the apparent K i values of 28.9, 55.0, and 39.8 μM, respectively. On the other hand, Δ9-THC, CBD, and CBN inhibited 7-benzoxyresorufin O-debenzylase activity of recombinant CYP2B6 in a mixed fashion with the K i values of 2.81, 0.694, and 2.55 μM, respectively. Because the inhibition of CYP2B6 by CBD was the most potent,
investigation was conducted to determine which moiety of the CBD
structure was responsible for the inhibition.....Δ9-THC, CBD, and CBN showed metabolism-dependent inhibition for CYP2A6 but not for CYP2B6.....These results indicated that Δ9-THC, CBD, and CBN showed differential inhibition against CYP2A6 and CYP2B6."
The report does not show any IC50 values, nor have I found any, and I only know that low values of Ki indicate high inhibiting potency.
If the cannabinoids listed above are metabolism-dependent for CYP2A6 inhibition, then would taking a metabolism booster such as cayenne pepper, also a potent CYP1A2 inhibitor, significantly increase inhibition of 2A6 by these cannabinoids?