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Ayahuasca fatality

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hendrix

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Jul 11 08 8:02 AM

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I was PM'd asking about the safety of using DMT. Check this out. It's a fatal ayahuasca case. This is from PubMed: http://www.ncbi.nlm.nih.gov/pubmed/16356341

J Anal Toxicol. 2005 Nov-Dec;29(8):838-41.

A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation.

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Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Rockville, Maryland 20850, USA.

Abstract

A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic tryptamines is presented. No anatomic cause of death was found at autopsy. Toxicologic analysis of the heart blood identified N,N-dimethyltryptamine (0.02 mg/L), 5-methoxy-N,N-dimethyltryptamine (1.88 mg/L), tetrahydroharmine (0.38 mg/L), harmaline (0.07 mg/L), and harmine (0.17 mg/L). All substances were extracted by a single-step n-butyl chloride extraction following alkalinization with borate buffer. Detection and quantitation was performed using liquid chromatography-electrospray mass spectrometry. The medical examiner ruled that the cause of death was hallucinogenic amine intoxication, and the manner of death was undetermined.

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hendrix

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Jul 11 08 8:12 AM

It's mainly 5-MeO-DMT, not DMT that they are talking about. DMT is about 1/2 as toxic according to animal tests. Nothing is completely safe. Most people are using plants to make DMT from, and many DMT containing plants also have 5-MeO-DMT. It gets extracted with the DMT and makes it more dangerous. Be careful using impure DMT extracted from unknown sources. Mimosa contains some weird unknown shit in it. Chacruna is probably safer to extract DMT from.


I know of one case where pure DMT was nearly fatal by injection. It's documented in one of Ott's books. None of these things are completely safe. Always use caution when playing with mind altering drugs.



People, this is why you research things before you do them. Ending up dead like that guy above is not cool. The guy was 25, had his whole life ahead of him. Now he's dead, just cause he wanted to trip.

Between the eyes and ears there lie The sounds of colour and the light of a sigh

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toastus

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Jul 11 08 8:46 AM

Phalaris brachystachys is pure DMT, SWIM has it growing near his house.

Thanks for the information. This supports the hypothesis that hallucinogens work by affecting the glutamate system, too, because overstimulation of cells kills them!

How toxic are other psychedelics? What is the method by which they kill you?

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#5 [url]

Sep 23 11 12:06 AM

People have no idea how easy it is to die from DMT. it's literally a 'dye' and you can't clear it without monoamine oxidase.
The second point is about the methyl group. Methylation of DNA is an important maintenance marker and also the central focus of epigenetics.
DMT contains a methyl group, whereas cubensis alkaloids are acetylated and phosphorylated psilocin (psilacetin and psilocybin). You can overdose on any of these, and the molecules are small enough to get in and touch the DNA and interfere with active processes. For example, a large dose of 4-aco apparently inhibits some acetyltransferase or deacetylase. Psilocybin may itself compete with ATP for metabolisim, its presence without fail will interfere with the krebs cycle.

Its not so farfetched to think that an excess of undigested DMT might act as a methyl group donor. Interference with this system appears to disrupt the balance of homeostasis.

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