Some people even get paradoxical effects from it, it depends on the amount of each alkaloids in the strain you're using.
Something else interesting is that kava inhibit CYP1A2 and CYP3A4, while inducing CYP2A6 and CYP3A4 but not their catalytic activity, just their production. So, i decided to try it(6 encapsulated grams of hawaïan kava) with a 10X extract of Macropiper Exelsum(500mg) wich contains myristicin and a little elemicin. From what i know of the chemical content of Maori kava, it was about 2.5 mg of myristicin and at least ten times less of elemicin. Even if you consider grapefruit juice as not effective, i will mention it because i drank two cups of it a couple hours before.
It worked very well and it was low on visuals but the physical component of it was really nice, maybe like MDMA(not sure because i just tried it 2 or 3 times and pills are oftenly sold "as" being something). This was quite an experiment for me because there was almost no hangover unlike with synth drugs.
I tought of it a little and came to the conclusion that this was probably a synergy between grapefruit juice and kava. It is also probable that i am really sensitive to those substances.
P.S.: Sorry if i made mistakes, english is not my native language.