As far as I know, the only allylbenzene that requires CYP2D6 is elemicin. CYP2D6 inhibitors do not seem to inactivate allylbenzenes other than elemicin.
If you lack the ability to make CYP2D6, and some people do, you can’t get psychedelic effects from elemicin. It’s impossible. I know for sure that high levels of CYP2D6 are needed for elemicin to have mescaline-like effects. In me, all CYP2D6 inhibitors inactivate elemicin until the inhibition wears off. For example, a dose of 300 mg of piperine causes elemicin to have no effects at all in me until about 3 hours after its CYP2D6 inhibition effects wear off. At that point, elemicin becomes active in me. Without the piperine, elemicin is active within 20 minutes usually in me. With 2 cups of white grapefruit juice, elemicin is inactive for 6-8 hours in me, and becomes active very slowly afterwards, because white grapefruit juice inhibits CYP2D6 for a longer period than piperine does. CYP2D6 inhibition from white grapefruit juice lasts about 2 days.
A lot of things inhibit CYP2D6. Many drugs do, some fruit juices do, some common supplements do.
Valerian root oil is supposed to induce CYP2D6. I know it goes very well with elemicin, and absolutely makes it more visual for me. Does it really induce CYP2D6? I’m not sure. But it enhances the effects of elemicin for me. I mix it with it often.
In me, the effects of eugenol vary depending on the inhibitors I use with it. All forms of it are active in me, and somewhat similar. None are “psychedelic”. On it’s own, I find the effects somewhat unpleasant. Its like being drunk. I get mentally intoxicated. I feel tingling all over, the sort of tingling that I get from the pain relievers at the dentist. These effects are more noticeable if I take it by mouth without a capsule. If I take it in a capsule with German chamomile oil, which is a CYP1A2 inhibitor, the effects of eugenol are less sedating for me. It’s much nicer. If I take it in a capsule with a CYP2D6 inhibitor, like 2 cups of white grapefruit juice, the effects are very nice. It feels like an anti-depressant. Very uplifting, lots of euphoria, etc.
Eugenol easily passes through your stomach walls, and avoids digestion if you don’t take it in a capsule. Eugenol is like DMSO in that way. It easily permeates membranes. Like DMSO, eugenol helps drugs soak through your skin.
The CYP2D6 enzyme turns eugenol into hydroxychavicol. But this doesn’t happen that easily because a lot of the eugenol just soaks through the walls of the stomach, bypassing CYP2D6 metabolism.
Hydroxychavicol is a potent anti-oxidant that helps fight cancer, a potent xanthine oxidase inhibitor, and it also prevents tooth decay by killing the germs that often cause oral cavities.
Its interesting how a lot of allylbenzenes that were once thought to cause cancer are now showing promise as cancer fighting agents. I guess when real non-government funded, non-propaganda studies are made about these allylbenzenes, the truth gets out. I wouldn’t be surprised if we eventually find out that safrole helps fight cancer too. All of the studies that I know of that showed it to be carcinogenic were government funded studies, and they used several known tricks that can make almost anything appear carcinogenic. Since there’s never been a single case of a human developing cancer from drinking sassafras tea (which is high in safrole), I get the feeling those tests were just government propaganda created to get safrole banned because it’s used to make MDMA.