Ah good, I too was wondering about Eugenol and Methyl Eugenol too. A quick question, even though I will research more about it later...just pressed for time right now, but what differences are there between Eugenol and Methyl Eugenol? Any difference in effects, if bioassay has been done.
Also, look into 2C9. The studies I've seen have found it to be just as important as 1A2. It can be found as a strong inhibitor in Ginkgo biloba.
Ginkgo biloba has proven to be a bad choice when it comes to visual psychedelics in general. A lot of people have said it greatly diminishes visual effects. I’ve seen this said for bufotenine (SWIM verified this himself), DMT, and quite a few other psychedelics. It has vasodilating effects in the wrong part of the body, similar to theobromine, which is also know to reduce visuals, at least in some people. For me, chocolate greatly diminishes elemicin’s visuals if I have enough to feel the effects of the theobromine. Others have also noticed this with other psychedelics. But paradoxically, some people get potentiation from theobromine, especially when used in ayahuasca.
I think Ginkgo is probably better with ayahuasca than with other psychedelics. I think the hamala alkaloids in ayahuasca potentiate psychedelics enough that Ginkgo cannot diminish their effects.
For me, Ginkgo completely overpowers elemicin, making it not the slightest bit psychedelic. Large doses of chocolate also seem to do this.
Yesterday I took several doses of phenethylamine (a legal stimulant), and then later several doses of phenylalanine (a legal amino acid which can be made into phenethylamine in humans) to compare the two. And then I took elemicin with phenylalanine, expecting potentiation. It pretty much made the elemicin inactive.
I’m not sure why chocolate, Ginkgo, and phenylalanine (or possibly phenethylamine) are detrimental to the effects of elemicin. White grapefruit juice and black pepper are also. What these do to inhibit the psychedelic effects of elemicin is unknown. With white grapefruit and black pepper, I believe it’s their CYP2D6 inhibition that weakens and prolongs the effects of elemicin. But why the others inactivate elemicin is probably somehow related to their effects on blood vessels.
Caffeine potentiates elemicin, mescaline, and phenethylamine and can help get rid of headaches. LSA/LSH/LSD can also help get rid of headaches. Theobromine can cause headaches in me. Ginkgo, like theobromine and phenylalanine can also cause headaches. This relates to their effects on blood vessels. I think this effect is anti-hallucinogenic.
Like you said, CYP2C9 is probably a good enzyme to inhibit, but a better inhibitor needs to be found, one that’s more psychedelic friendly. For myristicin and safrole, but not elemicin and methyl chavicol, CYP2D6 is also probably good to inhibit, if you want a more MDMA like effect rather than a MDA like effect. MDA is more visual than MDMA. MDA is created from MDMA by CYP2D6.
Quercetin is a potent CYP2C9 inhibitor which also inhibits CYP3A4, CYP1A2, and CYP2A6. It’s also a mild MAO-A inhibitor and very mild MAO-B inhibitor. This is available OTC at some sports nutrition centers. I have this and I’m planning to give it a few tests with elemicin. It’s effect’s of CYP2D6 are not well documented. I have read that quercetin totally ruins the effects of codeine, so it may strongly inhibit CYP2D6. I believe anything that messes up the effects of codeine will be detrimental to elemicin as well. We’ll see.
Turmeric is also a potent CYP2C9 inhibitor which also inhibits CYP3A4, CYP1A2, and CYP1A1, but is said to induce CYP2A6. This doesn’t seem to go well with elemicin, but I haven’t tested it enough to be sure.
Apigenin is a potent CYP2C9 inhibitor that’s found in German chamomile but not in the oil. This is available OTC in pure form. I have noticed that the flowers are a little better than the oil, but not much. The fact that you need to take 5-10 grams of flowers as apposed to 3-8 drops of the oil, makes the oil so much better in my opinion.
5-hydroxyeugenol is also a potent CYP2C9 inhibitor.
White grapefruit and black pepper are also potent CYP2C9 inhibitors, but they also inhibit CYP2D6, and they are horrible with elemicin, but apparently good for myristicin and safrole.
Eugenol inhibits CYP2C9 pretty strongly. This is good with elemicin, as long as the dose is low. If the dose is too high it interferes with the euphoria of elemicin and introduces a cloudy drifty drunken feeling.
Methyl eugenol seems to go well with elemcin however, making the experience feel more like DMT. This needs more testing to be sure of it though. Mexican allspice is very high in methyl eugenol, and very low in eugenol. I have this at home. It’s effects are nothing like those of eugenol. However CYP2D6 should be able to O-demethylate methyl eugenol into both eugenol and chavibetol. Perhaps inhibiting CYP2D6 will be beneficial for methyl eugenol?
3,4-Dimethoxyamphetamine is the amphetamine version of methyl eugenol. It’s psychedelic. See here:
3,4-Dimethoxyphenethylamine is the phenethylamine version of methyl eugenol. It’s probably only active with an MAO inhibitor. See here:
It’s my belief that the n,n-dimethyl-3,4-dimethoxyphenethylamine version of methyl eugenol would be the “active” metabolite, if it’s active. I don’t think these oils form phenethylamines or amphetamines, but rather they form n,n-dimethylphenethylamines.