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Homemade enteric coated capsules - how it's done
To make homemade enteric coated capsules you fill a standard gelatin capsule with your alkaloid, oil, or other active substance, and then you close the capsule. You then dip the capsule in food grade shellac. You then dry the capsules completely and then dip them again. Dry and repeat one more time, and dry once more. This produces a coating that’s insoluble in water that can’t be penetrated by stomach acids.
Any kind of non-toxic shellac can be used. It must say on the package that’s it’s non-toxic when dry. “Food grade” shellac is simply standard non-toxic shellac mixed with ethanol. The same stuff is sold at hardware stores.
Enteric coated capsules have great utility for things that either upset the stomach or must be digested in the intestines. The following is just a list of ideas to get started with:
* it can completely block the nausea caused by mescaline by disallowing the mescaline to absorb in the walls of the stomach.
* it will prevent many drugs from re-salting to hydrochlorides by bypassing the hydrochloric acid in the stomach secretions. This can be of great benefit for some things. Possibly freebase bufotenine will benefit from this, allowing it to be absorbed in the intestines as freebase bufotenine rather than the nauseating bufotenine HCl.
* it should allow elemicin to work better. It seems that elemicin doesn’t work well unless it’s digested in the intestines.
* it allows you to make capsules that are water resistant, and better protected from the environment. Enteric coated capsules will last longer.
This information is taken from drugs.com:
Shellac NF is food grade and is listed as Generally Recognized as Safe (GRAS) by the FDA.
Shellac is the purified product of lac, the red, hardened secretion of the insect Laccifer (Tachardia) lacca Kerr. This tiny insect sucks the sap of selected trees and bushes, and secretes lac as a protective covering. The name lac is said to derive from lakh , the Sanskrit word for one hundred thousand, a reference to the very large number of insects involved in producing appreciable amounts of the product.
Lac is cultivated in India, Thailand, and Burma. The whitest lac is produced by insects infesting the kusum tree ( Schleichera trijuga ). The harvester cuts twigs coated with lac into small pieces called sticklac. The crude material is ground and soaked in water to remove debris and insect bodies. The remaining material is soaked in sodium carbonate, which removes laccaic acid, a complex mixture of at least four structurally related pigments. The resulting granules retain the yellow pigment erythrolaccin and are dried to form seedlac. Further treatment by melting, evaporating, or filtering yields shellac.
The National Formulary XV recognizes 4 grades of shellac: Orange, dewaxed orange, regular bleached and refined wax-free bleached. The grades differ in the manner in which the seedlac is treated. Orange shellac is obtained by the evaporation of filtered ethanolic solutions of seedlac. It may be dewaxed by further filtration. Regular bleached shellac is obtained by dissolving the seedlac in aqueous sodium carbonate at a high temperature. After filtration, a bleaching agent (such as sodium hypochlorite) is added. The resin is removed by sulfuric acid precipitation. Refined wax-free bleached shellac adds another filtration step to remove the waxes.
The exact chemical composition of shellac is unknown. It appears to be composed of a network of hydroxy fatty acid esters and sesquiterpene acid esters with a molecular weight of about 1000. Aleuretic acid, r-butolic acid, shellolic acid, and jalaric acid are the major constituents. The composition is a function of the source and time of harvest of the sticklac. Variability in the product may be a problem for commercial users of shellac. The physical properties of shellac also vary. For example, the reported melting point ranges from 77° to 120°C. Shellac is soluble in ethanol, methanol, glycols, glycol ethers, and alkaline water.
This info is from http://antiquerestorers.com/Articles/jeff/shellac.htm
Pharmaceutical - shellac is used to coat enteric pills so that they do not dissolve in the stomach, but in the lower intestine, which alleviates upset stomachs. Its also used as a coating on pills to "time release" medication.
Food Coatings - because of its FDA approval, shellac is used to coat apples and other fruits to make them shinier.