INCI means The International Nomenclature of Cosmetic Ingredients. Acorus Calamus Oil is an INCI standard name. That's all that means.
I don't know the smell of coumarin.
I looked at a lot of different calamus GC data from different parts of the world. They very SO WIDELY. Some are mostly methyl eugenol. Some are very high in elemicin. Some are a bit high in gamma-asarone, etc. Some have none of these. They are so different from each other.
All the calamus I have from Nepal is amber in color. The oil from India is yellow. If I were to compare either with nutmeg, the oil from Nepal would be closer to nutmeg. But both are still very different from nutmeg.
India produces more than 1 kind of calamus oil. Not all are free of gamma-asarone apparently.
Activation of gamma-asarone should be the same as that for methyl chavicol, elemicin and methyl eugenol (but not things like safrole, dillapiole, apiole, or myristicin).
The most important things to help activate gamma-asarone should be (in bold):
* potently inhibit CYP2D6 (7 grams of black pepper as filtered tea works)
* inhibit UGT (valerian root oil, licorice root)
* inhibit Glutathione S-transferase (Ellagic acid)
* inhibit SULT (EGCG, ECG)
* induce 17bHSD2 (Gallic acid, Palm oil carotenoids, Retinoic acid, Vitamin D3)
* induce CYP2C9, or other similar P450 enzymes that can 1'-hydroxylate (vitmain B9 does this)
CYP2D6 is a major problem in the P450 realm when it comes to methoxy groups. We can't have methoxy groups metabolized into hydroxy groups on the benzene ring. Elemicin, methyl eugenol, methyl chavicol, and gamma-asarone will have no psychedelic action if they are O-demethylated. It doesn't matter if you inhibit the other enzymes if this happens. It's impossible for the O-demethylated allylbenzenes to be psychedelic. So if you don't have things to inhibit the other enzymes at least potently inhibit CYP2D6. This is the single most important step. Everything else depends on there being no hydroxy groups on the benzene ring.
Something in my oil from Nepal inhibits CYP2D6 very strongly, but I don't know what it is. My oil from India is weak at inhibiting CYP2D6.
Black pepper tea made from 7 grams of black pepper, filtered, works very well to inhibit CYP2D6.
DO NOT TAKE PIPERINE TO INHIBIT CYP2D6. IT WILL PROBABLY NOT WORK. There is no evidence that I could find that piperine inhibits CYP2D6 to any degree. Other compounds in black pepper are proven to potently inhibit CYP2D6 in vitro. See here: http://herbpedia.wikidot.com/cyp2d6
All I know is that whole black pepper messes things up for me at any dose of 5 grams or more. Black pepper tea works wonders at 7 grams. Piperine has very poor solubility in water. So black pepper tea has very little piperine in it. I believe piperine does something to mess up the activation. I'm not sure what it does exactly. But filtering black pepper tea makes it work way better and that action removes most of the piperine but extracts the other alkaloids that are proven to inhibit CYP2D6 in vitro.
Whole black pepper seems to be a double edged sword. Piperine seems very bad for activation, while the other water soluble actives are great for activation.