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I'm planning on trialing this 'stack' at some point in the near future. [source]
Cannabis (or marijuana) is a very useful tool for creative thinking and expanded logic (Studies have shown). But Studies have also shown that, although cannabis doesn't kill brain cells, marijuana's effects reduce memory function in a few different ways.
Some benefits of this supplement include: Reversing some tolerance, reversing memory loss, speeding detoxification of THC, correcting some hormonal effects, potientially helping immune system, and improving overall memory.
Main ways Cannabis reduces memory:
1. Residual CB1 agonist release from fatty cells.
2. cAMP/ CREB (Chemical responsible for Long-Term memory potential) decrease will result in less memories being encoded.
3. NGF (Nerve Growth Factor) decrease lowers the maintenance and growth of new neurons.
4. Decrease in Glutaminergic brain activity (via GABA) (causes a lowered mental energy and could make someone lazy/tired).
A natural proven intoxication blocker. Studies show this type of chemical diminishes all memory impairments caused by THC. Contains a chemical called ampelopsin that influences GABA(a) receptors in an inhibitory fashion. This compound not only reverses memory effects caused by GABA, it also prevents long term anxiety caused by THC. This compound can be used to reverse even non-drug induced anxiety. 8' 13'
Proven to increase metabolism of THC to its inactive version 11-nor-9-carboxy. This means american ginseng is a working detox. Prevents CB1 activation after intoxication, reducing ones tolerance. American Ginseng also contains CB1 Inverse agonist falcarinol (Studies show it reverses CB1s effects at certain sites). Some slight hormonal type improvements have also been noted. American Ginseng also increases dopamine production in certain areas of the brain improving memory and tolerance. American Ginseng also works as a choline uptake enhancer exactly as Aniracetam, Piracetam and most of the other racetams (nootropics) do. 7' 10' 11' 17'
This natural compound has been found to relieve anxiety and stress in the gut without effecting gaba receptors or memory! Marijuana has been shown to increase stress and anxiety aswell as weaken the immune system. Lysine helps to reverse both of these aspects.
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Bacopa has been shown to increase working memory as well as long term retention. Bacopa also reduces the possibility of seizure. This makes overdose from Dihydromyricetin nearly impossible even at unsafe amounts. Bacopa has also been shown to reverse amnesia caused by gaba down regulation with an unknown mechanism. Bacopasides has also been found to thwart brain inflammation caused from smoke and lipoxygenase. 1' 6' 9'
Studies have shown it is very beneficial with boosting the effects of NGF. Studies show it helps ATP production. Uridine relies on ATP to exert its effects, thus proving synergistic effects between the two. Aceytl-L-Carnitine also works synergistically with l-glutamine, increasing the activation of glutaminase, the enzyme responsible with converting glutamine into glutamate (most abundant neurotransmitter in the brain). Studies also show it improves mental performance greatly. 12' 14' 16'